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Biochemistry news

Fueling the MATE transporter

Evolutionarily conserved transport proteins, such as those belonging to the multidrug and toxic compound extrusion (MATE) superfamily, protect cells against toxic chemicals and contribute to multidrug resistance in cancer ...

date4 hours ago in Biochemistry
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Chemists characterize the fatal fungus among us

Life-threatening fungal infections affect more than two million people worldwide. Effective antifungal medications are very limited. Until now, one of the major challenges is that the fungal cell wall is poorly understood, ...

dateJul 19, 2018 in Biochemistry
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Infrared sensor as new method for drug discovery

Using an infrared sensor, biophysicists at Ruhr-Universität Bochum (RUB) have succeeded in analysing quickly and easily which active agents affect the structure of proteins and how long that effect lasts. Thus, Prof Dr. ...

dateJul 19, 2018 in Biochemistry
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Protecting ribosome genes to prevent aging

Aging is a process of gradual deterioration from exposure to time and the elements; this process begins with deterioration deep inside every cell. Researchers from Stanford University and the VA Palo Alto Health Care System ...

dateJul 16, 2018 in Biochemistry
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The secret sulfate code that lets the bad Tau in

Vampires can turn humans into vampires, but to enter a human's house, they must be invited in. Researchers at the UT Southwestern Medical Center, writing in the Journal of Biological Chemistry, have uncovered details of how ...

dateJul 13, 2018 in Biochemistry
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New computational method for drug discovery

HITS researchers developed tauRAMD, a tool to predict drug-target residence times from short simulations. The method is illustrated on the cover page of July 2018 issue of the Journal of Chemical Theory and Computation, software ...

dateJul 12, 2018 in Biochemistry
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Discovery of new type of antibiotic

A new type of antibiotic may help millions of COPD patients and children with middle ear infections. The drug is unlikely to have any side effects and has the great advantage that no resistance development can occur. Researchers ...

dateJul 11, 2018 in Biochemistry
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Supercoil me! The art of knotted DNA maintenance

Even living cells have their own tangled problems to solve. They involve knots that arise accidentally in DNA and that can comprise its functionality. Researchers now suggest that the DNA propensity to be supercoiled, just ...

dateJul 06, 2018 in Biochemistry
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New insight into the maturation of miRNAs

An international research team led by Helmholtz Zentrum München, Technical University of Munich and the University of Edinburgh has used an integrated structural biological approach to elucidate the maturation of a cancer-causing ...

Designer enzyme uses unnatural amino acid for catalysis

University of Groningen chemists have created a new enzyme with an unnatural amino acid as its active centre. They made the enzyme by modifying an antibiotic binding protein which normally acts as a bacterial transcription ...

Scavengers "protect" HDL

High-density lipoprotein (HDL) is widely thought to protect against the development of atherosclerosis, yet drugs that raise levels of HDL cholesterol (HDL-C) have failed to reduce the risk of heart disease.

New staph virulence factor

Staphylococcus aureus (staph) is a leading cause of hospital-acquired infections and an increasing threat to public health. Enzymes called serine hydrolases modulate host-pathogen interactions, but little is known about this ...

Team reports technology to enable precision antibiotics

Scientists are searching for ways to develop antibiotics that can accurately target infectious bacteria. Increased specificity could help to combat antibiotic resistance and also spare "good" bacteria from being attacked ...

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A phonon laser operating at an exceptional point
Where to search for signs of life on Titan
Houseplants could one day monitor home health
Researchers report two-faced Janus membrane applications
Solving the mystery of an unusual medieval text
Putting bacteria to work
LC10 – the neuron that tracks fruit flies
Human influence detected in changing seasons
Study finds key to plant growth control mechanism
Targeting headaches and tumors with nano-submarines
A physics treasure hidden in a wallpaper pattern

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